In vitro activity of LY 264826 compared with that of vancomycin against 100 clinical isolates each of methicillin-resistant Staphylococcus aureus and Clostridium difficile

Author:

Fasola E L1,Moody J A1,Gerding D N1,Peterson L R1

Affiliation:

1. Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis 55417.

Abstract

The in vitro activity of LY 264826, a new glycopeptide antibiotic, was compared with that of vancomycin against 100 strains each of methicillin-resistant Staphylococcus aureus and Clostridium difficile. LY 264826 was more active, by weight, than vancomycin against the isolates tested. The human serum protein binding of LY 264826 was 15.3% (range, 9.8 to 21.8%).

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Reference7 articles.

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3. National Committee for Clinical Laboratory Standards. 1988. Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically 2nd ed. Tentative standard M7-T2. National Committee for Clinical Laboratory Standards Villanova Pa.

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