Ciprofloxacin does not inhibit mitochondrial functions but other antibiotics do

Author:

Riesbeck K1,Bredberg A1,Forsgren A1

Affiliation:

1. Department of Medical Microbiology, University of Lund, Malmö General Hospital, Sweden.

Abstract

At clinical concentrations, ciprofloxacin did not inhibit mitochondrial DNA replication, oxidative phosphorylation, protein synthesis, or mitochondrial mass (transmembrane potential). No difference in supercoiled forms of DNA was observed. The tetracyclines and chloramphenicol inhibited protein synthesis at clinically achievable concentrations, while rifampin, fusidic acid, and clindamycin did not.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Reference35 articles.

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4. Castora F. J. R. Sternglanz and M. V. Simpson. 1982. A new mitochondrial topoisomerase from rat liver that catenates DNA p. 143-154. In P. Slominski P. Borst and G. Attardi (ed.) Mitochondrial genes. Cold Spring Harbor Laboratory Cold Spring Harbor N.Y.

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