Genomic Investigation Reveals Contaminated Detergent as the Source of an Extended-Spectrum-β-Lactamase-Producing Klebsiella michiganensis Outbreak in a Neonatal Unit-Reference-Cited by-同舟云学术

Genomic Investigation Reveals Contaminated Detergent as the Source of an Extended-Spectrum-β-Lactamase-Producing Klebsiella michiganensis Outbreak in a Neonatal Unit

Published:2020-04-23 Issue:5 Volume:58 Page:
ISSN:0095-1137
Container-title:Journal of Clinical Microbiology
language:en
Short-container-title:J Clin Microbiol

Author:

Chapman Paul¹²³,Forde Brian M.⁴^ORCID,Roberts Leah W.⁴,Bergh Haakon⁵,Vesey Debra²,Jennison Amy V.⁶^ORCID,Moss Susan⁶⁷,Paterson David L.¹⁷,Beatson Scott A.⁴^ORCID,Harris Patrick N. A.⁵⁷^ORCID

Affiliation:

1. Infectious Diseases Unit, Royal Brisbane and Women’s Hospital, Herston, QLD, Australia

2. Infection Prevention and Control, Caboolture Hospital, Caboolture, QLD, Australia

3. Queensland Institute of Medical Research Berghofer, Herston, QLD, Australia

4. School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD, Australia

5. Microbiology Department, Central Laboratory, Pathology Queensland, Royal Brisbane and Women’s Hospital, Herston, QLD, Australia

6. Public Health Microbiology, Forensic, and Scientific Services, Queensland Health, Brisbane, QLD, Australia

7. University of Queensland Centre for Clinical Research, Royal Brisbane and Women’s Hospital, Herston, QLD, Australia

Abstract

Klebsiella species are problematic pathogens in neonatal units and may cause outbreaks, for which the sources of transmission may be challenging to elucidate. We describe the use of whole-genome sequencing (WGS) to investigate environmental sources of transmission during an outbreak of extended-spectrum-β-lactamase (ESBL)-producing Klebsiella michiganensis colonizing neonates. Ceftriaxone-resistant Klebsiella spp. isolated from neonates (or their mothers) and the hospital environment were included.

Funder

Australian Government Research Training Program

Queensland Genomics Health Alliance

Department of Health | National Health and Medical Research Council

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Link

https://journals.asm.org/doi/pdf/10.1128/JCM.01980-19

Reference38 articles.

1. Outbreaks of extended spectrum beta-lactamase-producing Enterobacteriaceae in neonatal intensive care units: a systematic review