Affiliation:
1. Department of Microbiology and Immunology, University of British Columbia, Vancouver, British Columbia, Canada
Abstract
Human immunodeficiency virus (HIV) disproportionally infects young women in sub-Saharan Africa. Current HIV-1 prevention options have had limited success among women, suggesting that alternative, female-controlled prevention options need to be developed. Microbicides that can be applied to the vaginal tract are a promising prevention option. In this study, we describe the testing of 15 potential candidates for inhibition of HIV-1 infection in a humanized mouse model of HIV-1 infection. Four of these candidates were able to provide significant protection from vaginal infection with HIV-1, with the most successful candidate protecting 75% of the mice from infection. This study describes the preclinical testing of a new strategy that could be a safe and effective option for HIV-1 prevention in women.
Funder
Canadian HIV Trials Network, Canadian Institutes of Health Research
Publisher
American Society for Microbiology
Subject
Virology,Insect Science,Immunology,Microbiology
Reference62 articles.
1. UNAIDS. 2018. Global HIV & AIDS statistics—2018 fact sheet. http://www.unaids.org/en/resources/fact-sheet.
2. Effectiveness and Safety of Tenofovir Gel, an Antiretroviral Microbicide, for the Prevention of HIV Infection in Women
3. Tenofovir-Based Preexposure Prophylaxis for HIV Infection among African Women
4. Rossi L. 2011. Microbicide trials network statement on decision to discontinue use of tenofovir gel in VOICE, a major HIV prevention study in women. Microbicide Trials Network, Pittsburgh, PA.
5. Preexposure Prophylaxis for HIV Infection among African Women
Cited by
7 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献