Effect of Pregnancy on the Pharmacokinetic Interaction between Efavirenz and Lumefantrine in HIV-Malaria Coinfection-Reference-Cited by-同舟云学术

Effect of Pregnancy on the Pharmacokinetic Interaction between Efavirenz and Lumefantrine in HIV-Malaria Coinfection

Published:2018-10 Issue:10 Volume:62 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Adegbola Adebanjo¹,Abutaima Rana²,Olagunju Adeniyi¹²^ORCID,Ijarotimi Omotade³,Siccardi Marco²,Owen Andrew²,Soyinka Julius¹,Bolaji Oluseye¹

Affiliation:

1. Department of Pharmaceutical Chemistry, Obafemi Awolowo University, Ile Ife, Nigeria

2. Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, United Kingdom

3. Department of Obstetrics and Gynaecology, Obafemi Awolowo University, Ile Ife, Nigeria

Abstract

Artemether-lumefantrine is often coadministered with efavirenz-based antiretroviral therapy for malaria treatment in HIV-infected women during pregnancy. Previous studies showed changes in lumefantrine pharmacokinetics due to interaction with efavirenz in nonpregnant adults.

Funder

Tertiary Education Trust Fund

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01252-18

Reference37 articles.

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2. World Health Organization. 2015. Guidelines for the treatment of malaria. World Health Organization, Geneva, Switzerland.

3. World Health Organization. 2016. Consolidated guidelines on the use of antiretroviral drugs for treating and preventing HIV infection. World Health Organization, Geneva, Switzerland.

4. Treatment of Malaria in Pregnancy

5. Four Artemisinin-Based Treatments in African Pregnant Women with Malaria

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