Inner Mitochondrial Translocase Tim50 Is Central in Adrenal and Testicular Steroid Synthesis-Reference-Cited by-同舟云学术

Inner Mitochondrial Translocase Tim50 Is Central in Adrenal and Testicular Steroid Synthesis

Published:2019-01 Issue:1 Volume:39 Page:
ISSN:0270-7306
Container-title:Molecular and Cellular Biology
language:en
Short-container-title:Mol Cell Biol

Author:

Bose Himangshu S.¹²,Gebrail Fadi³,Marshall Brendan⁴,Perry Elizabeth W.⁴,Whittal Randy M.⁵

Affiliation:

1. Laboratory of Biochemistry, Biomedical Sciences, Mercer University School of Medicine, Savannah, Georgia, USA

2. Anderson Cancer Institute, Memorial University Medical Center, Savannah, Georgia, USA

3. Laboratory of Pathology, Memorial University Medical Center, Savannah, Georgia, USA

4. Department of Cell Biology and Anatomy, Augusta State University, Augusta, Georgia, USA

5. Department of Chemistry, University of Alberta, Edmonton, Alberta, Canada

Abstract

Adrenal and gonadal mitochondrial metabolic activity requires electrons from cofactors, cholesterol, and a substrate for rapid steroid synthesis, an essential requirement for mammalian survival. Substrate activity depends on its environment, which is regulated by chaperones and mitochondrial translocases.

Funder

NIH

Publisher

American Society for Microbiology

Subject

Cell Biology,Molecular Biology

Link

https://journals.asm.org/doi/pdf/10.1128/MCB.00484-18

Reference48 articles.

1. Functional and Genomic Analyses Reveal an Essential Coordination between the Unfolded Protein Response and ER-Associated Degradation

2. MAM: more than just a housekeeper

3. Prefoldin-nascent chain complexes in the folding of cytoskeletal proteins;Hansen WJ;J Cell Physiol,1999