In Vitro Adsorption of Gentamicin and Netilmicin by Polyacrylonitrile and Polyamide Hemofiltration Filters-Reference-Cited by-同舟云学术

In Vitro Adsorption of Gentamicin and Netilmicin by Polyacrylonitrile and Polyamide Hemofiltration Filters

Published:2010-02 Issue:2 Volume:54 Page:963-965
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

K.N. Lam Philip¹,Tian Qi¹,Ip Margaret²,Gomersall Charles D.¹

Affiliation:

1. Department of Anaesthesia and Intensive Care, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, N.T., Hong Kong

2. Department of Microbiology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, N.T., Hong Kong

Abstract

ABSTRACT Adsorption of gentamicin and netilmicin by new polyacrylonitrile and polyamide hemofiltration filters was studied over 4 h, using a single-compartment in vitro continuous venovenous hemofiltration model. After the first dose (16.6 mg of gentamicin, 19.3 mg of netilmicin), 14.9 mg of gentamicin and 19.2 mg of netilmicin were adsorbed to polyacrylonitrile filters in vitro . Adsorption by polyacrylonitrile filters was rapid and irreversible and could be increased by repeated dosing. Adsorption by polyamide filters was substantially less.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01215-09

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