Biofilms of Mycobacterium abscessus Complex Can Be Sensitized to Antibiotics by Disaggregation and Oxygenation-Reference-Cited by-同舟云学术

Biofilms of Mycobacterium abscessus Complex Can Be Sensitized to Antibiotics by Disaggregation and Oxygenation

Published:2020-01-27 Issue:2 Volume:64 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Kolpen Mette¹^ORCID,Jensen Peter Østrup¹²³,Qvist Tavs⁴,Kragh Kasper Nørskov¹³,Ravnholt Cecillie¹,Fritz Blaine Gabriel³,Johansen Ulla Rydahl¹,Bjarnsholt Thomas¹³^ORCID,Høiby Niels¹³

Affiliation:

1. Department of Clinical Microbiology, Rigshospitalet, Copenhagen, Denmark

2. Institute for Inflammation Research, Center for Rheumatology and Spine Diseases, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark

3. Costerton Biofilm Center, Institute of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

4. Copenhagen CF Center, Department of Infectious Diseases, Rigshospitalet, Copenhagen, Denmark

Abstract

Pulmonary infection with the multidrug-resistant Mycobacterium abscessus complex (MABSC) is difficult to treat in individuals with cystic fibrosis (CF). MABSC grows as biofilm aggregates in CF patient lungs, which are known to have anaerobic niches. How aggregation and anoxic conditions affect antibiotic tolerance is not well understood. We sought to determine whether disaggregation and oxygen availability sensitize MABSC isolates to recommended antibiotics.

Funder

Technology and Production Sciences

Human Frontier Science Program

Lundbeckfonden

Cystic Fibrosis Foundation

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01212-19

Reference56 articles.