Affiliation:
1. Vaccine Department, Statens Seruminstitut, Copenhagen, Denmark.
Abstract
An infection model of human tuberculosis was established with C57BL/6J mice. The lymphocyte proliferative responses to antigens from Mycobacterium tuberculosis were investigated during the course of infection and compared with results obtained with a group of mice immunized with large amounts of killed bacteria. The two groups responded similarly to a number of mycobacterial antigens, but marked differences in responses against secreted antigens were found; only infected mice responded vigorously to these. The responding lymphocyte subpopulation was made up of L3T4+ T lymphocytes under restriction of the Ia molecule.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Immunology,Microbiology,Parasitology
Reference30 articles.
1. Characterization of fibronectin-binding antigens released by Mycobacterium tuberculosis and Mycobacterium bovis BCG;Abou-Zeid C.;Infect. Immun.,1988
2. The secreted antigens of Mycobacterium tuberculosis and their relationship to those recognized by the available antibodies;Abou-Zeid C.;J. Gen. Microbiol.,1988
3. Interspecies reactivity of five monoclonal antibodies to Mycobacterium tuberculosis as examined by immunoblotting and enzyme-linked immunosorbent assay;Andersen A. B.;J. Clin. Microbiol.,1986
4. Andersen P. D. Askgaard L. Ljungqvist J. Bennedsen and I. Heron. Submitted for publication.
5. Characterization of T cell antigens associated with the cell wall protein-peptidoglycan complex of Mycobacterium tuberculosis;Barnes P. F.;J. Immunol.,1989
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