Serum (1-3)-β- d -Glucan as a Tool for Diagnosis of Pneumocystis jirovecii Pneumonia in Patients with Human Immunodeficiency Virus Infection or Hematological Malignancy-Reference-Cited by-同舟云学术

Serum (1-3)-β- d -Glucan as a Tool for Diagnosis of Pneumocystis jirovecii Pneumonia in Patients with Human Immunodeficiency Virus Infection or Hematological Malignancy

Published:2009-12 Issue:12 Volume:47 Page:3871-3874
ISSN:0095-1137
Container-title:Journal of Clinical Microbiology
language:en
Short-container-title:J Clin Microbiol

Author:

Desmet Stefanie¹,Van Wijngaerden Eric²,Maertens Johan³,Verhaegen Jan¹,Verbeken Eric⁴,De Munter Paul²,Meersseman Wouter²,Van Meensel Britt¹,Van Eldere Johan¹,Lagrou Katrien¹

Affiliation:

1. Departments of Medical Diagnostic Sciences

2. General Internal Medicine

3. Hematology

4. Pathology, University Hospitals Leuven, Herestraat 49, 3000 Leuven, Belgium

Abstract

ABSTRACT (1-3)-β- d -Glucan (BG) reactivity was tested in serum samples from 28 patients with human immunodeficiency virus infection or a hematological malignancy and Pneumocystis jirovecii pneumonia (PCP) and 28 control patients. The sensitivity and specificity of BG detection with the Fungitell assay for PCP were 100 and 96.4%, respectively, using a cutoff value of 100 pg/ml. Serum BG testing looks promising for the noninvasive diagnosis of PCP. Our data suggest that a higher cutoff value for the diagnosis of PCP than for the diagnosis of invasive aspergillosis or candidiasis could be used safely and will improve the specificity of the test.

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Link

https://journals.asm.org/doi/pdf/10.1128/JCM.01756-09

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