Affiliation:
1. Department of Microbiology, Colorado State University, Fort Collins, Colorado 80523
Abstract
ABSTRACT
It was determined that the dTDP-rhamnose synthesis gene,
rmlD
, could be inactivated in
Mycobacterium smegmatis
only in the presence of a rescue plasmid carrying functional
rmlD.
Hence, dTDP-rhamnose biosynthesis is essential for the growth of mycobacteria and the targeting of dTDP-rhamnose synthesis for new tuberculosis drugs is supported.
Publisher
American Society for Microbiology
Subject
Molecular Biology,Microbiology
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