Compound FC-10696 Inhibits Egress of Marburg Virus-Reference-Cited by-同舟云学术

Compound FC-10696 Inhibits Egress of Marburg Virus

Published:2021-06-17 Issue:7 Volume:65 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Han Ziying¹,Ye Hong²,Liang Jingjing¹,Shepley-McTaggart Ariel¹,Wrobel Jay E.²,Reitz Allen B.²,Whigham Alison³,Kavelish Katrina N.³,Saporito Michael S.⁴,Freedman Bruce D.¹,Shtanko Olena³,Harty Ronald N.¹^ORCID

Affiliation:

1. University of Pennsylvania, Philadelphia, Pennsylvania, USA

2. Fox Chase Chemical Diversity Center, Doylestown, Pennsylvania, USA

3. Texas Biomedical Research Institute, San Antonio, Texas, USA

4. Intervir, LLC, Philadelphia, Pennsylvania, USA

Abstract

Marburg virus (MARV) VP40 protein (mVP40) directs egress and spread of MARV, in part, by recruiting specific host WW domain-containing proteins via its conserved PPxY late (L) domain motif to facilitate efficient virus-cell separation. We reported previously that small-molecule compounds targeting the viral PPxY/host WW domain interaction inhibited VP40-mediated egress and spread.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

Wellcome

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00086-21

Reference48 articles.

1. Marburg and Ebola Viruses

2. Modular mimicry and engagement of the Hippo pathway by Marburg virus VP40: Implications for filovirus biology and budding