Antigenic Relationship Between Serotype-Specific Agglutinogen and Fimbriae of Bordetella pertussis

Author:

Ashworth L. A. E.1,Irons L. I.1,Dowsett A. B.1

Affiliation:

1. Pathogenic Microbes Research Laboratory, Centre for Applied Microbiology and Research, Porton Down, Salisbury, Wiltshire SP4 OJG, Great Britain

Abstract

The widely held view that the filamentous hemagglutinin (FHA) of Bordetella pertussis is derived from fimbriae (pili) is not supported by studies of fimbriation and FHA content of the organism. Fimbriae do not label specifically with antibody to FHA in immuno-electron microscopy but do label with antibody to serotype-specific agglutinogen.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Reference15 articles.

1. Fimbrial hemagglutinin in stationary and shake cultures of Bordetella pertlmssis;Arai H.;Infect. Immun.,1979

2. Separation and characterization of two distinct haemagglutinins contained in purified leukocytosis-promoting factor from Bordetella perttussis;Arai H.;Biochim. Biophys. Acta,1976

3. Rabbit nasopharyngeal colonization by Bordetella pertlussis: the effects of immunization on clearance and on serum and nasal antibody levels;Ashworth L. A. E.;J. Hyg.,1982

4. Heterogeneity of the filamentous haemagglutinin of Bordetella pertuissis detected with monoclonal antibodies;Irons L. I.;Soc. Gen. Microbiol. Q.,1982

5. Irons L. I. and A. P. MacLennan. 1979. Substrate specificity and the purification by affinity combination methods of the two Bordetella pertussis hemagglutinins. p. 338-349. In C. R. Manclark and J. C. Hill (ed.) International NOTES 1281

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