In Vivo Colonization with Candidate Oral Probiotics Attenuates Streptococcus mutans Colonization and Virulence

Author:

Culp David J.1ORCID,Hull William1,Bremgartner Matthew J.1,Atherly Todd A.1,Christian Kacey N.1,Killeen Mary1,Dupuis Madeline R.1,Schultz Alexander C.1,Chakraborty Brinta1,Lee Kyulim1,Wang Deneen S.1,Afzal Verisha1,Chen Timmy1,Burne Robert A.1ORCID

Affiliation:

1. UF College of Dentistry, Department of Oral Biology, Gainesville, Florida, USA

Abstract

Our results demonstrate that in vivo testing of potential oral probiotics can be accomplished and can yield information to facilitate the ultimate design and optimization of novel anticaries probiotics. We show that human oral commensals associated with dental health are an important source of potential probiotics that may be used to colonize patients under dietary conditions of highly various cariogenicity.

Funder

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Ecology,Applied Microbiology and Biotechnology,Food Science,Biotechnology

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