First Detection of TR34 L98H and TR46 Y121F T289A Cyp51 Mutations in Aspergillus fumigatus Isolates in the United States-Reference-Cited by-同舟云学术

First Detection of TR34 L98H and TR46 Y121F T289A Cyp51 Mutations in Aspergillus fumigatus Isolates in the United States

Published:2016-01 Issue:1 Volume:54 Page:168-171
ISSN:0095-1137
Container-title:Journal of Clinical Microbiology
language:en
Short-container-title:J Clin Microbiol

Author:

Wiederhold Nathan P.¹,Gil Veronica Garcia²,Gutierrez Felipe³⁴,Lindner Jonathan R.¹,Albataineh Mohammad T.¹,McCarthy Dora I.¹,Sanders Carmita¹,Fan Hongxin¹,Fothergill Annette W.¹,Sutton Deanna A.¹

Affiliation:

1. University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA

2. Hospital Universitario La Paz, Madrid, Spain

3. Phoenix VA Healthcare, Phoenix, Arizona, USA

4. University of Arizona College of Medicine, Phoenix, Arizona, USA

Abstract

ABSTRACT Azole resistance in Aspergillus fumigatus is an increasing problem. The TR34 L98H and TR46 Y121F T289A mutations that can occur in patients without previous azole exposure have been reported in Europe, Asia, the Middle East, Africa, and Australia. Here, we report the detection of both the TR34 L98H and TR46 Y121F T289A mutations in confirmed A. fumigatus isolates collected in institutions in the United States. These mutations, other mutations known to cause azole resistance, and azole MICs are reported here.

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Link

https://journals.asm.org/doi/pdf/10.1128/JCM.02478-15

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