Detection of Antibodies to Toxin-Coregulated Pili in Sera from Cholera Patients-Reference-Cited by-同舟云学术

Detection of Antibodies to Toxin-Coregulated Pili in Sera from Cholera Patients

Published:2004-03 Issue:3 Volume:72 Page:1824-1827
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Attridge Stephen R.¹,Wallerström Gun²,Qadri Firdausi³,Svennerholm Ann-Mari²

Affiliation:

1. Department of Molecular Biosciences, The University of Adelaide, Adelaide, South Australia, Australia

2. Department of Medical Microbiology and Immunology, University of Göteborg, Göteborg, Sweden

3. Centre for Health and Population Research, International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh

Abstract

ABSTRACT Monoclonal antibodies (MAbs) were prepared against toxin-coregulated pili (TCP) isolated from Vibrio cholerae O1 El Tor. Despite their limited bactericidal potential, two MAbs were able to mediate biotype-specific protection against experimental cholera in infant mice. These MAbs were used in immunoblotting studies to assess seroconversion to El Tor TCP following cholera. Clear anti-pilus responses were observed in five of nine patients.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.72.3.1824-1827.2004

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