Depressed Gamma Interferon Responses and Treatment Outcomes in Tuberculosis Patients: a Prospective Cohort Study

Author:

Feng Jia-Yih123,Pan Sheng-Wei124,Huang Shiang-Fen5,Chen Ying-Ying1,Lin Yung-Yang3678,Su Wei-Juin12

Affiliation:

1. Department of Chest Medicine, Taipei Veterans General Hospital, Taipei, Taiwan

2. School of Medicine, National Yang-Ming University, Taipei, Taiwan

3. Institute of Clinical Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan

4. Institute of Public Health, National Yang-Ming University, Taipei, Taiwan

5. Division of Infectious Disease, Department of Internal Medicine, Taipei Veterans General Hospital, Taipei, Taiwan

6. Division of Cerebrovascular Diseases, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan

7. Institute of Brain Science, National Yang-Ming University, Taipei, Taiwan

8. Department of Critical Care Medicine, Taipei Veterans General Hospital, Taipei, Taiwan

Abstract

Immunosuppression induced by Mycobacterium tuberculosis is important in the pathogenesis of active tuberculosis (TB). However, the impact of depressed TB-specific and non-TB-specific gamma interferon (IFN-γ) response on the treatment outcomes of TB patients remains uncertain.

Funder

Taipei Veterans General Hospital

Ministry of Science and Technology, Taiwan

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Reference30 articles.

1. WHO. 2017. Global tuberculosis report 2016. World Health Organization Geneva Switzerland. http://apps.who.int/iris/bitstream/10665/250441/1/9789241565394-eng.pdf?ua=1.

2. WHO. 2015. The End TB Strategy. World Health Organization Geneva Switzerland. http://www.who.int/tb/End_TB_brochure.pdf?ua=1.

3. Taiwan Centers for Disease Control. 2016. Taiwan tuberculosis control report 2016. Taiwan Centers for Disease Control, Ministry of Health and Welfare, Taiwan. https://www.cdc.gov.tw/uploads/files/201712/2bf81c5a-4812-4977-9c02-388aadba77a7.pdf.

4. Initial Presentations Predict Mortality in Pulmonary Tuberculosis Patients - A Prospective Observational Study

5. Determinants of mortality in elderly patients with tuberculosis: a population-based follow-up study

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