Affiliation:
1. The Lilly Research Laboratories, Eli Lilly & Co., Indianapolis, Indiana 46206
Abstract
Structural analysis of two new β-lactam antibiotics, A16884A and A16886B, indicated that they, like cephalosporin C, were composed of modified valine and cysteine residues, and α-aminoadipic acid. However, acid hydrolysis of A16886B and A16884A produced three times as much glycine as did hydrolysis of cephalosporin C under the same conditions. Samples of A16886B-
14
C-6
and A16886B-
14
C-8
were prepared by the addition of cysteine-
14
C-3
and cystine-
14
C-1
to fermentations of
Streptomyces clavuligerus
. The specific activity of glycine obtained from hydrolysis of A16886B-
14
C-6
was considerably higher than that from hydrolysis of A16886B-
14
C-8
. An explanation for the difference in amounts of glycine obtained from hydrolysis of these antibiotics is discussed.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
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5. ft-Lactam antibiotics from Streptomyces;Nagarajan R.;J. Amer. Chem. Soc.,1971
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