E2F6-Mediated Downregulation of MIR22HG Facilitates the Progression of Laryngocarcinoma by Targeting the miR-5000-3p/FBXW7 Axis-Reference-Cited by-同舟云学术

E2F6-Mediated Downregulation of MIR22HG Facilitates the Progression of Laryngocarcinoma by Targeting the miR-5000-3p/FBXW7 Axis

Published:2020-04-28 Issue:10 Volume:40 Page:
ISSN:0270-7306
Container-title:Molecular and Cellular Biology
language:en
Short-container-title:Mol Cell Biol

Author:

Chen Hui¹,Ali Mudunov²,Ruben Azizyan²,Stelmakh Dimitry²,Pak Maksim²

Affiliation:

1. I. M. Sechenov First Moscow State Medical University, Moscow, Russian Federation

2. N. N. Blokhin National Medical Research Center of the Oncology of the Ministry of Health of the Russian Federation, Moscow, Russian Federation

Abstract

Recently, abundant evidence has clarified that long noncoding RNAs (lncRNAs) play an oncogenic or anticancer role in the tumorigenesis and development of diverse human cancers. Described as a crucial regulator in some cancers, MIR22HG has not yet been studied in laryngocarcinoma and therefore the underlying regulatory role of MIR22HG in laryngocarcinoma is worth detecting. In this study, MIR22HG expression in laryngocarcinoma cells was confirmed to be downregulated, and upregulated MIR22HG expression led to suppressive effects on laryngocarcinoma cell proliferation and migration.

Funder

None

Publisher

American Society for Microbiology

Subject

Cell Biology,Molecular Biology

Link

https://journals.asm.org/doi/pdf/10.1128/MCB.00496-19

Reference34 articles.

1. World cancer report 2014—Geneva, Switzerland: World Health Organization, International Agency for Research on Cancer, WHO Press, 2015;McGuire S;Adv Nutr,2016

2. Cancer Statistics for Hispanics/Latinos, 2018

3. Biomarkers of head and neck cancer, tools or a gordian knot?;Lampri ES;Int J Clin Exp Med,2015