Identification of Novel Mutations Contributing to Azole Tolerance of Aspergillus fumigatus through In Vitro Exposure to Tebuconazole-Reference-Cited by-同舟云学术

Identification of Novel Mutations Contributing to Azole Tolerance of Aspergillus fumigatus through In Vitro Exposure to Tebuconazole

Published:2021-08-17 Issue:9 Volume:65 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Toyotome Takahito¹²³^ORCID,Onishi Kenji¹,Sato Mio¹,Kusuya Yoko³,Hagiwara Daisuke³⁴⁵^ORCID,Watanabe Akira³^ORCID,Takahashi Hiroki³⁶⁷^ORCID

Affiliation:

1. Department of Veterinary Medicine, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido, Japan

2. Diagnostic Center for Animal Health and Food Safety, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido, Japan

3. Medical Mycology Research Center, Chiba University, Chiba, Chiba, Japan

4. Faculty of Life and Environmental Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan

5. Microbiology Research Center for Sustainability, University of Tsukuba, Tsukuba, Ibaraki, Japan

6. Molecular Chirality Research Center, Chiba University, Chiba, Chiba, Japan

7. Plant Molecular Science Center, Chiba University, Chiba, Chiba, Japan

Abstract

Azole resistance of Aspergillus fumigatus is a global problem. The major resistance mechanism is through cytochrome P 450 14-α sterol demethylase Cyp51A alterations such as a mutation(s) in the gene and the acquisition of a tandem repeat in the promoter.

Funder

Japan Agency for Medical Research and Development

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.02657-20

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