Comparative Study of Activities of a Diverse Set of Antimycobacterial Agents against Mycobacterium tuberculosis and Mycobacterium ulcerans-Reference-Cited by-同舟云学术

Comparative Study of Activities of a Diverse Set of Antimycobacterial Agents against Mycobacterium tuberculosis and Mycobacterium ulcerans

Published:2016-05 Issue:5 Volume:60 Page:3132-3137
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Scherr Nicole¹²,Pluschke Gerd¹²,Panda Manoranjan³

Affiliation:

1. Swiss Tropical and Public Health Institute, Basel, Switzerland

2. University of Basel, Basel, Switzerland

3. Department of Chemistry, iMED Infection, AstraZeneca India Pvt. Ltd., Hebbal, Bangalore, India

Abstract

ABSTRACT A library of compounds covering a broad chemical space was selected from a tuberculosis drug development program and was screened in a whole-cell assay against Mycobacterium ulcerans , the causative agent of the necrotizing skin disease Buruli ulcer. While a number of potent antitubercular agents were only weakly active or inactive against M. ulcerans , five compounds showed high activity (90% inhibitory concentration [IC 90 ], ≤1 μM), making screening of focused antitubercular libraries a good starting point for lead generation against M. ulcerans .

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.02658-15

Reference34 articles.

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2. A Mycobacterium ulcerans Toxin, Mycolactone, Causes Apoptosis in Guinea Pig Ulcers and Tissue Culture Cells

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4. All-Oral Antibiotic Treatment for Buruli Ulcer: A Report of Four Patients

5. In Vitro and In Vivo Activities of Rifampin, Streptomycin, Amikacin, Moxifloxacin, R207910, Linezolid, and PA-824 against Mycobacterium ulcerans

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