Poxvirus CD8 + T-Cell Determinants and Cross-Reactivity in BALB/c Mice-Reference-Cited by-同舟云学术

Poxvirus CD8 + T-Cell Determinants and Cross-Reactivity in BALB/c Mice

Published:2006-07 Issue:13 Volume:80 Page:6318-6323
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Tscharke David C.¹²,Woo Wai-Ping²,Sakala Isaac G.³,Sidney John⁴,Sette Alessandro⁴,Moss Denis J.²,Bennink Jack R.¹,Karupiah Gunasegaran³,Yewdell Jonathan W.¹

Affiliation:

1. Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892-0440

2. Division of Immunology and Infectious Diseases, Queensland Institute of Medical Research, Herston QLD 4006, Australia

3. Division of Immunology and Genetics, John Curtin School of Medical Research, Australian National University, Canberra ACT 2601, Australia

4. Division of Translational Immunology and Biodefense, La Jolla Institute for Allergy and Immunology, San Diego, California 92121

Abstract

ABSTRACT Mouse models of orthopoxvirus disease provide great promise for probing basic questions regarding host responses to this group of pathogens, which includes the causative agents of monkeypox and smallpox. However, some essential tools for their study that are taken for granted with other mouse models are not available for these viruses. Here we map and characterize the initial CD8 + T-cell determinants for poxviruses in H-2 d -haplotype mice. CD8 + T cells recognizing these three determinants make up around 40% of the total responses to vaccinia virus during and after resolution of infection. We then use these determinants to test if predicted conservation across orthopoxvirus species matches experimental observation and find an unexpectedly cross-reactive variant peptide encoded by ectromelia (mousepox) virus.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.00427-06

Reference32 articles.

1. Belyakov, I. M., P. Earl, A. Dzutsev, V. A. Kuznetsov, M. Lemon, L. S. Wyatt, J. T. Snyder, J. D. Ahlers, G. Franchini, B. Moss, and J. A. Berzofsky. 2003. Shared modes of protection against poxvirus infection by attenuated and conventional smallpox vaccine viruses. Proc. Natl. Acad. Sci. USA100:9458-9463.

2. Bowie, A., E. Kiss-Toth, J. A. Symons, G. L. Smith, S. K. Dower, and L. A. O'Neill. 2000. A46R and A52R from vaccinia virus are antagonists of host IL-1 and toll-like receptor signaling. Proc. Natl. Acad. Sci. USA97:10162-10167.

3. RESPONSE OF MICE TO ECTROMELIA AND VACCINIA VIRUSES

4. Bronte, V., M. W. Carroll, T. J. Goletz, M. Wang, W. W. Overwijk, F. Marincola, S. A. Rosenberg, B. Moss, and N. P. Restifo. 1997. Antigen expression by dendritic cells correlates with the therapeutic effectiveness of a model recombinant poxvirus tumor vaccine. Proc. Natl. Acad. Sci. USA94:3183-3188.

5. Chang, H. W., J. C. Watson, and B. L. Jacobs. 1992. The E3L gene of vaccinia virus encodes an inhibitor of the interferon-induced, double-stranded RNA-dependent protein kinase. Proc. Natl. Acad. Sci. USA89:4825-4829.

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