Stabilization but No Functional Influence of HIF-1α Expression in the Intestinal Epithelium during Salmonella Typhimurium Infection-Reference-Cited by-同舟云学术

Stabilization but No Functional Influence of HIF-1α Expression in the Intestinal Epithelium during Salmonella Typhimurium Infection

Published:2022-02-17 Issue:2 Volume:90 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Robrahn Laura¹^ORCID,Dupont Aline²,Jumpertz Sandra¹,Zhang Kaiyi²^ORCID,Holland Christian H.³⁴⁵^ORCID,Guillaume Joël⁶,Rappold Sabrina¹,Roth Johanna¹,Cerovic Vuk⁶,Saez-Rodriguez Julio³⁴⁵^ORCID,Hornef Mathias W.²^ORCID,Cramer Thorsten¹⁷⁸⁹¹⁰^ORCID

Affiliation:

1. Department of General, Visceral and Transplantation Surgery, RWTH Aachen University Hospital, Aachen, Germany

2. Institute of Medical Microbiology, RWTH Aachen University Hospital, Aachen, Germany

3. Institute for Computational Biomedicine, Faculty of Medicine, Heidelberg University, Heidelberg, Germany

4. Heidelberg University Hospital, Bioquant, Heidelberg, Germany

5. Joint Research Center for Computational Biomedicine, RWTH Aachen University Hospital, Aachen, Germany

6. Institute of Molecular Medicine, RWTH University Hospital, Aachen, Germany

7. ESCAM—European Surgery Center Aachen Maastricht, Aachen, Germany

8. ESCAM—European Surgery Center Aachen Maastricht, Maastricht, The Netherlands

9. Department of Surgery, Maastricht University Medical Center, Maastricht, The Netherlands

10. NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University, Maastricht, The Netherlands

Abstract

Hypoxia-inducible transcription factor 1 (HIF-1) has been shown to enhance microbial killing and ameliorate the course of bacterial infections. While the impact of HIF-1 on inflammatory diseases of the gut has been studied intensively, its function in bacterial infections of the gastrointestinal tract remains largely elusive.

Funder

Deutsche Forschungsgemeinschaft

RWTH Aachen | Medizinische Fakultät, RWTH Aachen University

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/iai.00222-21

Reference79 articles.

1. Advances in Hypoxia-Inducible Factor Biology

2. Activation of Hypoxia Inducible Factor 1 Is a General Phenomenon in Infections with Human Pathogens