Immunoreactive Protein Repertoires of Ehrlichia chaffeensis and E. canis Reveal the Dominance of Hypothetical Proteins and Conformation-Dependent Antibody Epitopes-Reference-Cited by-同舟云学术

Immunoreactive Protein Repertoires of Ehrlichia chaffeensis and E. canis Reveal the Dominance of Hypothetical Proteins and Conformation-Dependent Antibody Epitopes

Published:2021-10-15 Issue:11 Volume:89 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Luo Tian¹^ORCID,Patel Jignesh G.¹,Zhang Xiaofeng¹,Walker David H.¹²³⁴,McBride Jere W.¹⁵²³⁴^ORCID

Affiliation:

1. Department of Pathology, University of Texas Medical Branch, Galveston, Texas, USA

2. Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical Branch, Galveston, Texas, USA

3. Sealy Institute for Vaccine Sciences, University of Texas Medical Branch, Galveston, Texas, USA

4. Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, Texas, USA

5. Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, USA

Abstract

The immunomes of Ehrlichia chaffeensis and Ehrlichia canis have recently been revised to include immunodominant hypothetical proteins with conformational antibody epitopes. In this study, we examined 216 E. chaffeensis and 190 E. canis highly antigenic proteins according to ANTIGENpro and also performed a genome-wide hypothetical protein analysis ( E. chaffeensis n = 104; E. canis n = 124) for immunoreactivity.

Funder

Clayton Foundation for Research

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.00224-21

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