Acquisition of IgG to ICAM-1-Binding DBLβ Domains in the Plasmodium falciparum Erythrocyte Membrane Protein 1 Antigen Family Varies between Groups A, B, and C-Reference-Cited by-同舟云学术

Acquisition of IgG to ICAM-1-Binding DBLβ Domains in the Plasmodium falciparum Erythrocyte Membrane Protein 1 Antigen Family Varies between Groups A, B, and C

Published:2019-10 Issue:10 Volume:87 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Olsen Rebecca W.¹,Ecklu-Mensah Gertrude²,Bengtsson Anja¹,Ofori Michael F.²,Kusi Kwadwo A.²,Koram Kwadwo A.³,Hviid Lars¹⁴^ORCID,Adams Yvonne¹,Jensen Anja T. R.¹^ORCID

Affiliation:

1. Centre for Medical Parasitology at Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

2. Department of Immunology, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana

3. Department of Epidemiology, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana

4. Department of Infectious Diseases, Copenhagen University Hospital (Rigshospitalet), Copenhagen, Denmark

Abstract

Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) is an important malaria virulence factor. The protein family can be divided into clinically relevant subfamilies. ICAM-1-binding group A PfEMP1 proteins also bind endothelial protein C receptor and have been associated with cerebral malaria in children. IgG to these PfEMP1 proteins is acquired later in life than that to group A PfEMP1 not binding ICAM-1.

Funder

Consultative Committee for Development Research

HHS | NIH | National Institute of Allergy and Infectious Diseases

Lundbeckfonden

Novo Nordisk Fonden

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.00224-19

Reference56 articles.