Pathways of activation of the Epstein-Barr virus productive cycle-Reference-Cited by-同舟云学术

Pathways of activation of the Epstein-Barr virus productive cycle

Published:1991-05 Issue:5 Volume:65 Page:2237-2244
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Sinclair A J¹,Brimmell M¹,Shanahan F¹,Farrell P J¹

Affiliation:

1. Ludwig Institute for Cancer Research, St. Mary's Hospital Medical School, Paddington, London, England.

Abstract

The promoter for the 2.8-kb RNA of Epstein-Barr virus encoding BZLF1 and BRLF1 was identified and shown to be activated by both BZLF1 and BRLF1 but not by 12-O-tetradecanoylphorbol-13-acetate. Site-directed mutagenesis suggests that two binding sites for BZLF1 within the promoter contribute to the transactivation by BZLF1. The early kinetics of induction of the 2.8- and 1.0-kb RNAs encoding BZLF1 and BRLF1 in Akata cells treated with anti-immunoglobulin indicate that both RNAs appear within 60 min. The results indicate some likely pathways of activation of Epstein-Barr virus productive cycle gene expression.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.65.5.2237-2244.1991

Reference37 articles.

1. Purification of biologically active globin messenger RNA by chromatography on oligothymidylic acid-cellulose;Aviv H.;Proc. Nati. Acad. Sci. USA,1972

2. DNA sequence and expression of the B95-8 Epstein-Barr virus genome;Baer R.;Nature (London),1984

3. Epstein-Barr virus induction by a serum factor. Characterization of the purified factor and the mechanism of its activation;Bauer G.;J. Biol. Chem.,1982

4. Epstein-Barr virus gene expression in P3HR1-superinfected Raji cells;Biggin M.;J. Virol.,1987

5. The Epstein-Barr virus (EBV) early protein EB2 is a post-transcriptional activator expressed under the control of EBV transcription factors EB1 and R;Buisson M.;J. Virol.,1989

Cited by 113 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Orbivirus NS4 Proteins Play Multiple Roles to Dampen Cellular Responses;Viruses;2023-09-12

2. Malignancy and viral infections in Sub-Saharan Africa: A review;Frontiers in Virology;2023-03-06

Epstein-Barr Virus-Encoded Products Promote Circulating Tumor Cell Generation: A Novel Mechanism of Nasopharyngeal Carcinoma Metastasis

;OncoTargets and Therapy;2020-01

4. Viral-Targeted Strategies Against EBV-Associated Lymphoproliferative Diseases;Frontiers in Oncology;2019-02-26

5. Epstein-Barr virus BRLF1 induces genomic instability and progressive malignancy in nasopharyngeal carcinoma cells;Oncotarget;2017-09-05