Identification of a consistent pattern of mutations in neurovirulent variants derived from the sabin vaccine strain of poliovirus type 2

Author:

Equestre M1,Genovese D1,Cavalieri F1,Fiore L1,Santoro R1,Perez Bercoff R1

Affiliation:

1. Laboratory of Virology, Istituto Superiore di Sanità, Rome, Italy.

Abstract

Complete nucleotide sequencing of the RNAs of two unrelated neurovirulent isolates of Sabin-related poliovirus type 2 revealed that two nucleotides and one amino acid (amino acid 143 in the major capsid protein VP1) consistently departed from the sequences of the nonneurovirulent poliovirus type 2 712 and Sabin vaccine strains. This pattern of mutation appeared to be a feature common to all neurovirulent variants of poliovirus type 2.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

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