Heat Inactivation Renders Sputum Safe and Preserves Mycobacterium tuberculosis RNA for Downstream Molecular Tests-Reference-Cited by-同舟云学术

Heat Inactivation Renders Sputum Safe and Preserves Mycobacterium tuberculosis RNA for Downstream Molecular Tests

Published:2019-04 Issue:4 Volume:57 Page:
ISSN:0095-1137
Container-title:Journal of Clinical Microbiology
language:en
Short-container-title:J Clin Microbiol

Author:

Sabiiti Wilber¹,Azam Khalide²,Esmeraldo Ezembro²,Bhatt Nilesh²,Rachow Andrea³⁴,Gillespie Stephen H.¹

Affiliation:

1. School of Medicine, University of St Andrews, St Andrews, United Kingdom

2. Instituto Nacional de Saúde (INS), Ministério da Saúde, Maputo, Mozambique

3. Division of Infectious Diseases and Tropical Medicine, University of Munich, Munich, Germany

4. German Centre for Infection Research (DZIF), Partner Site Munich, Munich, Germany

Abstract

The World Health Organization End Tuberculosis (TB) strategy has called for the development of—and increased access to—effective tools for diagnosis and treatment of TB disease. Mycobacterium tuberculosis , the causative agent of TB, is categorized as a highly infectious agent.

Funder

University of St Andrews

European and Developing Countries Clinical Trials Partnership

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Link

https://journals.asm.org/doi/pdf/10.1128/JCM.01778-18

Reference32 articles.

1. Feasibility, diagnostic accuracy, and effectiveness of decentralised use of the Xpert MTB/RIF test for diagnosis of tuberculosis and multidrug resistance: a multicentre implementation study

2. Assessment of the sensitivity and specificity of Xpert MTB/RIF assay as an early sputum biomarker of response to tuberculosis treatment