Serological Studies of the T and Tumor Antigens of the Oncogenic Simian Adenoviruses

Author:

Gilden Raymond V.123,Kern Jerome123,Heberling Richard L.123,Huebner Robert J.123

Affiliation:

1. Flow Laboratories Inc., Rockville, Maryland 20852

2. Southwest Foundation for Research and Education, San Antonio, Texas

3. National Institutes of Health, Bethesda, Maryland 20014

Abstract

Tumor-specific antigens and antisera were prepared for eight of the oncogenic simian adenoviruses. Complement-fixation tests revealed three distinct serological subgroups. This grouping was maintained in studies of virus-infected cells (T antigens) although high titered preparations were obtained for only the major subgroup I. The current grouping is as follows: (I) SV1, SV11, SV25, SV33, SV34, SV38; (II) SV20, SV23; (III) SA 7. Antigens from each subgroup were rapidly inactivated at 56 C, and group II and III antigens were also markedly inactivated at 37 C. One of the tumors (SV1) also contained SV40 T antigen, suggesting origin from a simian adenovirus-SV40 “hybrid.”

Publisher

American Society for Microbiology

Subject

General Pharmacology, Toxicology and Pharmaceutics,General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Medicine

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