Affiliation:
1. The Institute for Cancer Research, Fox Chase, Philadelphia, Pennsylvania 19111
Abstract
It is important to establish the stability of Australia antigen subtypes in chronic carriers in order to evaluate the validity of using immunological determinants as long-term epidemiological markers. In this study sequential blood samples containing Australia antigen from 31 chronic carriers were typed for determinants d, y, and w. The subjects included asymptomatic carriers from Rongelap Atoll in the Marshall Islands, Down's syndrome patients, and renal patients receiving hemodialysis treatment. The period of time between blood samples extended from 3 months to 11 years. In no case did the subtype change within any individual. It appears from these data that the Australia antigen subtypes are good long-term markers for epidemiological studies.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Immunology,Microbiology,Parasitology
Reference19 articles.
1. Detection of additional antigenic determinants of hepatitis B antigen;Bancroft W. H.;J. Immunol.,1972
2. Hepatitis and Australia antigen. Autosomal recessive inheritance of susceptibility to infection in humans;Blumberg B. S.;Proc. Nat. Acad. Sci. U.S.A.,1969
3. Australia antigen and hepatitis. Studies in asymptomatic people and lepromatous leprosy patients;Blumberg B. S.;Arch. Intern. Med.,1970
4. Family studies of a human serum isoantigen system (Australia antigen);Blumberg B. S.;Amer. J. Human Genet.,1966
5. The nature of Australia antigen and its relation to antigen-antibody complex formation;Blumberg B. S.;J. Exp. Med.,1971
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