Affiliation:
1. Department of Biological Sciences, University of California, Santa Barbara, California
Abstract
Gartner
, T. K. (University of California, Santa Barbara),
and E. Orias
. Effects of mutations to streptomycin resistance on the rate of translation of mutant genetic information. J. Bacteriol.
91:
1021–1028. 1966.—The effects of mutations to streptomycin resistance of independent origin upon the translation of suppressible mutant information were studied in an isogenic series of strains of
Escherichia coli
. The group of suppressible mutants included 1 mutation in the
z
gene of the
lac
operon of
E. coli
(O
0
2
allele), 12 mutations distributed among the two
r
II cistrons of T4, and 13 mutations distributed among at least five cistrons of phage T7. It was concluded that the mutations to streptomycin resistance cause a significant decrease in the rate of translation of the suppressible codons, and that this effect is limited to a few types of codons.
Publisher
American Society for Microbiology
Subject
Molecular Biology,Microbiology
Reference32 articles.
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