Pharmacokinetics of Gentamicin and Kanamycin During Hemodialysis

Author:

Danish Michele1,Schultz Robert1,Jusko William J.1

Affiliation:

1. Clinical Pharmacokinetics Laboratory, Departments of Pharmacy, Medicine, and Pharmaceutics, State University of New York at Buffalo and Millard Fillmore Hospital, Buffalo, New York 14209

Abstract

The pharmacokinetics of gentamicin, kanamycin, and creatinine were studied in patients undergoing hemodialysis. After intravenous injection of single doses of the drugs, 50 to 60% of the doses of both antibiotics were cleared from the body during a 6-h period; this occurred almost entirely by the hemodialysis process. No correlation was found between the dialysance of the aminoglycosides and creatinine. The pharmacokinetic data were used to make dosage regimen recommendations for treatment of hemodialysis patients with these antibiotics.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Reference23 articles.

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3. Symposium: what is adequate dialysis;Babb A. L.;Proc. Clin. Dialysis Transplant Forum,1971

4. Simplified, accurate method for antibiotic assay of clinical specimens;Bennett J. V.;Appl. Microbiol.,1966

5. Bennett W. M. I. Singer and C. H. Coggins. Guide to drug usage in adult patients with impaired renal function. J. Amer. Med. Ass. 233:991-997.

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