Pharmacokinetics of Gentamicin and Kanamycin During Hemodialysis-Reference-Cited by-同舟云学术

Pharmacokinetics of Gentamicin and Kanamycin During Hemodialysis

Published:1974-12 Issue:6 Volume:6 Page:841-847
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Danish Michele¹,Schultz Robert¹,Jusko William J.¹

Affiliation:

1. Clinical Pharmacokinetics Laboratory, Departments of Pharmacy, Medicine, and Pharmaceutics, State University of New York at Buffalo and Millard Fillmore Hospital, Buffalo, New York 14209

Abstract

The pharmacokinetics of gentamicin, kanamycin, and creatinine were studied in patients undergoing hemodialysis. After intravenous injection of single doses of the drugs, 50 to 60% of the doses of both antibiotics were cleared from the body during a 6-h period; this occurred almost entirely by the hemodialysis process. No correlation was found between the dialysance of the aminoglycosides and creatinine. The pharmacokinetic data were used to make dosage regimen recommendations for treatment of hemodialysis patients with these antibiotics.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.6.6.841

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