Expression of <i>Microcystis</i> Biosynthetic Gene Clusters in Natural Populations Suggests Temporally Dynamic Synthesis of Novel and Known Secondary Metabolites in Western Lake Erie-Reference-Cited by-同舟云学术

Expression of Microcystis Biosynthetic Gene Clusters in Natural Populations Suggests Temporally Dynamic Synthesis of Novel and Known Secondary Metabolites in Western Lake Erie

Published:2023-05-31 Issue:5 Volume:89 Page:
ISSN:0099-2240
Container-title:Applied and Environmental Microbiology
language:en
Short-container-title:Appl Environ Microbiol

Author:

Yancey Colleen E.¹^ORCID,Yu Fengan²,Tripathi Ashootosh²³⁴,Sherman David H.²⁴⁵⁶,Dick Gregory J.¹⁷^ORCID

Affiliation:

1. Department of Earth and Environmental Sciences, University of Michigan, Ann Arbor, Michigan, USA

2. Life Sciences Institute, University of Michigan, Ann Arbor, Michigan, USA

3. Natural Products Discovery Core, University of Michigan, Ann Arbor, Michigan, USA

4. Department of Medicinal Chemistry, University of Michigan, Ann Arbor, Michigan, USA

5. Department of Chemistry, University of Michigan, Ann Arbor, Michigan, USA

6. Department of Microbiology and Immunology, University of Michigan, Ann Arbor, Michigan, USA

7. Cooperative Institute for Great Lakes Research (CIGLR), University of Michigan, Ann Arbor, Michigan, USA

Abstract

Microcystis spp. dominate cyanobacterial harmful algal blooms (cyanoHABs) worldwide and pose significant threats to water quality through the production of secondary metabolites, many of which are toxic. While the toxicity and biochemistry of microcystins and several other compounds have been studied, the broader suite of secondary metabolites produced by Microcystis remains poorly understood, leaving gaps in our understanding of their impacts on human and ecosystem health.

Funder

Cooperative Institute of Great Lakes Research

HHS | National Institutes of Health

National Science Foundation

Publisher

American Society for Microbiology

Subject

Ecology,Applied Microbiology and Biotechnology,Food Science,Biotechnology

Link

https://journals.asm.org/doi/pdf/10.1128/aem.02092-22

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