Role of MUC5B during Group B Streptococcal Vaginal Colonization-Reference-Cited by-同舟云学术

Role of MUC5B during Group B Streptococcal Vaginal Colonization

Published:2022-04-26 Issue:2 Volume:13 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Burcham Lindsey R.¹,Bath Jade R.²,Werlang Caroline A.²,Lyon Laurie M.¹,Liu Naoko³,Evans Christopher³,Ribbeck Katharina²,Doran Kelly S.¹^ORCID

Affiliation:

1. Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, Colorado, USA

2. Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA

3. Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado School of Medicine, Aurora, Colorado, USA

Abstract

Mucin glycoproteins are a major component that contributes to the complexity of the female reproductive tract (FRT). Group B Streptococcus (GBS) is present in the FRT of 25–30% of healthy women, but during pregnancy can ascend to the uterus to cause preterm birth and fetal infection in utero. Here we show that a prominent mucin found in the FRT, MUC5B, promotes host defense by inhibiting GBS interaction with epithelial cells found in the FRT and ascension from the vagina to the uterus in vivo .

Funder

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mbio.00039-22

Reference21 articles.

1. Mucin expression and function in the female reproductive tract

2. Mucins and Mucus

3. The Double Life of Group B Streptococcus: Asymptomatic Colonizer and Potent Pathogen