Three Bacterial DedA Subfamilies with Distinct Functions and Phylogenetic Distribution-Reference-Cited by-同舟云学术

Three Bacterial DedA Subfamilies with Distinct Functions and Phylogenetic Distribution

Published:2023-04-25 Issue:2 Volume:14 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Todor Horia¹,Herrera Nadia¹^ORCID,Gross Carol A.¹²³^ORCID

Affiliation:

1. Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, California, USA

2. Department of Cell and Tissue Biology, University of California, San Francisco, San Francisco, California, USA

3. California Institute of Quantitative Biology, University of California, San Francisco, San Francisco, California, USA

Abstract

DedA family proteins are highly conserved and nearly ubiquitous integral membrane proteins found in archaea, bacteria, and eukaryotes. Recent work revealed that eukaryotic DedA proteins are phospholipid scramblases and that some bacterial DedA proteins are undecaprenyl phosphate flippases.

Funder

Burroughs Wellcome Fund

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mbio.00028-23

Reference38 articles.

1. In silico prediction of structure and function for a large family of transmembrane proteins that includes human Tmem41b

2. Topological analysis of a bacterial DedA protein associated with alkaline tolerance and antimicrobial resistance