Glycogen Metabolism in Candida albicans Impacts Fitness and Virulence during Vulvovaginal and Invasive Candidiasis

Author:

Miao Jian1,Regan Jessica1,Cai Chun2,Palmer Glen E.23ORCID,Williams David L.45,Kruppa Michael D.56,Peters Brian M.23ORCID

Affiliation:

1. Pharmaceutical Sciences Program, College of Graduate Health Sciences, University of Tennessee Health Science Center, Memphis, Tennessee, USA

2. Department of Clinical Pharmacy and Translational Science, College of Pharmacy, University of Tennessee Health Science Center, Memphis, Tennessee, USA

3. Department of Microbiology, Immunology, and Biochemistry, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, USA

4. Department of Surgery, Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee, USA

5. Center of Excellence in Inflammation, Infectious Disease, and Immunity, East Tennessee State University, Johnson City, Tennessee, USA

6. Department of Biomedical Sciences, Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee, USA

Abstract

Glycogen is a highly branched polymer of glucose and is used across the tree of life as an efficient and compact form of energy storage. Whereas glycogen metabolism pathways have been studied in model yeasts, they have not been extensively explored in pathogenic fungi.

Funder

China Scholarship Council

HHS | NIH | National Institute of Allergy and Infectious Diseases

HHS | NIH | National Institute of General Medical Sciences

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

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