CRISPR Screens Identify <i>Toxoplasma</i> Genes That Determine Parasite Fitness in Interferon Gamma-Stimulated Human Cells-Reference-Cited by-同舟云学术

CRISPR Screens Identify Toxoplasma Genes That Determine Parasite Fitness in Interferon Gamma-Stimulated Human Cells

Published:2023-04-25 Issue:2 Volume:14 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Krishnamurthy Shruthi¹,Maru Parag¹,Wang Yifan¹,Bitew Mebratu A.¹,Mukhopadhyay Debanjan¹,Yamaryo-Botté Yoshiki²,Paredes-Santos Tatiana C.¹,Sangaré Lamba O.¹,Swale Christopher³,Botté Cyrille Y.²^ORCID,Saeij Jeroen P. J.¹^ORCID

Affiliation:

1. Department of Pathology, Microbiology and Immunology, School of Veterinary Medicine, University of California Davis, Davis, California, USA

2. Apicolipid Team, Institute for Advanced Biosciences, CNRS UMR5309, INSERM U1209, Université Grenoble Alpes, Batiment Jean Roget, Grenoble, France

3. Team Host-Pathogen Interactions and Immunity to Infection, Institute for Advanced Biosciences (IAB), INSERM U1209, CNRS UMR5309, University Grenoble Alpes, Grenoble, France

Abstract

Toxoplasma infection causes serious complications in immunocompromised individuals and in the developing fetus. During infection, certain immune cells release a protein called interferon gamma that activates cells to destroy the parasite or inhibit its growth.

Funder

Université Grenoble Alpes

Indo-French Collaborative Research Project Grant

Région Auvergne-Rhône-Alpes

Agence Nationale de la Recherche

Alliance Française contre les Maladies Parasitaires

American Heart Association

Centre National de la Recherche Scientifique

Fondation pour la Recherche Médicale

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology