SARS-CoV-2 Variant Pathogenesis Following Primary Infection and Reinfection in Syrian Hamsters-Reference-Cited by-同舟云学术

SARS-CoV-2 Variant Pathogenesis Following Primary Infection and Reinfection in Syrian Hamsters

Published:2023-04-25 Issue:2 Volume:14 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Plunkard Jessica¹²^ORCID,Mulka Kathleen¹,Zhou Ruifeng³,Tarwater Patrick⁴,Zhong William³,Lowman Margaret²,Wong Amanda²,Pekosz Andrew¹³^ORCID,Villano Jason¹²

Affiliation:

1. Department of Molecular and Comparative Pathobiology, Johns Hopkins University, Baltimore, Maryland, USA

2. Research Animal Resources, Johns Hopkins University, Baltimore, Maryland, USA

3. W. Harry Feinstone Department of Molecular Microbiology and Immunology, The Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA

4. Department of Epidemiology and Biostatistics, Texas A&M University, College Station, Texas, USA

Abstract

With the continued circulation and emergence of new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants, understanding differences in the effects between the initial infection and a subsequent reinfection on disease pathogenesis is critical and highly relevant. This study characterizes Syrian hamsters as an animal model to study reinfection with SARS-CoV-2. Previous infection reduced the disease severity of reinfection with different SARS-CoV-2 variants.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mbio.00078-23

Reference70 articles.

1. COVID-19: Unmasking Emerging SARS-CoV-2 Variants, Vaccines and Therapeutic Strategies

2. Novel SARS-CoV-2 variants: the pandemics within the pandemic

3. Pango lineage designation and assignment using SARS-CoV-2 spike gene nucleotide sequences