SARS-CoV-2 Variant Pathogenesis Following Primary Infection and Reinfection in Syrian Hamsters

Author:

Plunkard Jessica12ORCID,Mulka Kathleen1,Zhou Ruifeng3,Tarwater Patrick4,Zhong William3,Lowman Margaret2,Wong Amanda2,Pekosz Andrew13ORCID,Villano Jason12

Affiliation:

1. Department of Molecular and Comparative Pathobiology, Johns Hopkins University, Baltimore, Maryland, USA

2. Research Animal Resources, Johns Hopkins University, Baltimore, Maryland, USA

3. W. Harry Feinstone Department of Molecular Microbiology and Immunology, The Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA

4. Department of Epidemiology and Biostatistics, Texas A&M University, College Station, Texas, USA

Abstract

With the continued circulation and emergence of new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants, understanding differences in the effects between the initial infection and a subsequent reinfection on disease pathogenesis is critical and highly relevant. This study characterizes Syrian hamsters as an animal model to study reinfection with SARS-CoV-2. Previous infection reduced the disease severity of reinfection with different SARS-CoV-2 variants.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

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