A Virus-Packageable CRISPR System Identifies Host Dependency Factors Co-Opted by Multiple HIV-1 Strains-Reference-Cited by-同舟云学术

A Virus-Packageable CRISPR System Identifies Host Dependency Factors Co-Opted by Multiple HIV-1 Strains

Published:2023-02-28 Issue:1 Volume:14 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Montoya Vanessa R.¹^ORCID,Ready Trine M.²,Felton Abby²,Fine Sydney R.²,OhAinle Molly²^ORCID,Emerman Michael²^ORCID

Affiliation:

1. Molecular and Cellular Biology Graduate Program, University of Washington, Seattle, Washington, USA

2. Divisions of Human Biology and Basic Sciences, Fred Hutchinson Cancer Center, Seattle, Washington, USA

Abstract

With a small genome of ~9.2 kb that encodes 14 major proteins, HIV must hijack host cellular machinery to successfully establish infection. These host proteins necessary for HIV replication are called “dependency factors.” Whole-genome, and then targeted screens were done to try to comprehensively identify all dependency factors acting throughout the HIV replication cycle.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

HHS | NIH | National Institute of General Medical Sciences

HHS | NIH | National Institute on Drug Abuse

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mbio.00009-23

Reference57 articles.

1. Global Analysis of Host-Pathogen Interactions that Regulate Early-Stage HIV-1 Replication