Single-Cell Imaging Shows That the Transcriptional State of the HIV-1 Provirus and Its Reactivation Potential Depend on the Integration Site-Reference-Cited by-同舟云学术

Single-Cell Imaging Shows That the Transcriptional State of the HIV-1 Provirus and Its Reactivation Potential Depend on the Integration Site

Published:2022-08-30 Issue:4 Volume:13 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Janssens Julie¹^ORCID,De Wit Flore¹,Parveen Nagma²,Debyser Zeger¹^ORCID

Affiliation:

1. Molecular Virology and Gene Therapy, KU Leuven, Leuven, Belgium

2. Department of Chemistry, Indian Institute of Technology, Kanpur, India

Abstract

A longstanding question exists on the impact of the HIV-1 integration site on viral gene expression. This unsolved question has significant implications for the search toward an HIV-1 cure, as eradication strategies set up to reactivate and eliminate HIV-1 depend on the site where the provirus is integrated.

Funder

Fonds Wetenschappelijk Onderzoek

KU Leuven research council

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mbio.00007-22

Reference67 articles.

1. HIV integration sites and implications for maintenance of the reservoir

2. The site of HIV-1 integration in the human genome determines basal transcriptional activity and response to Tat transactivation