Phenotypic Profiling of Macrocyclic Lactones on Parasitic <i>Schistosoma</i> Flatworms-Reference-Cited by-同舟云学术

Phenotypic Profiling of Macrocyclic Lactones on Parasitic Schistosoma Flatworms

Published:2023-02-16 Issue:2 Volume:67 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Ryan Kaetlyn T.¹,Wheeler Nicolas J.¹²,Kamara Isaac K.³,Johnson Hailey³,Humphries Judith E.⁴,Zamanian Mostafa¹^ORCID,Chan John D.¹³^ORCID

Affiliation:

1. Department of Pathobiological Sciences, University of Wisconsin - Madison, Madison, Wisconsin, USA

2. Department of Biology, University of Wisconsin - Eau Claire, Eau Claire, Wisconsin, USA

3. Department of Chemistry, University of Wisconsin - Oshkosh, Oshkosh, Wisconsin, USA

4. Department of Biology, Lawrence University, Appleton, Wisconsin, USA

Abstract

Macrocyclic lactones are front-line therapies for parasitic roundworm infections; however, there are no comprehensive studies on the activity of this drug class against parasitic flatworms. Ivermectin is well known to be inactive against flatworms.

Funder

National Institutes of Health

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/aac.01230-22

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