Affiliation:
1. Tsukuba Research Institute, Banyu Pharmaceutical Co., Ltd., Japan.
Abstract
BO-2727, a new 1-beta-methyl-carbapenem, was active at concentrations of 6.25 micrograms/ml or less against gram-positive and gram-negative bacteria, including some imipenem- and/or meropenem-resistant (MICs, > or = 12.5 micrograms/ml) Pseudomonas aeruginosa strains, against which it proved generally fourfold more active than imipenem and meropenem. BO-2727's antipseudomonal activity and its broad spectrum merit further investigation for clinical use by itself, since it was stable in the presence of renal dehydropeptidase I.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Reference14 articles.
1. Characterization of 1-lactamases;Bush K.;Antimicrob. Agents Chemother.,1989
2. Standards for determining minimum inhibitory concentrations (MICs);Japan Society of Chemotherapy.;Chemotherapy (Tokyo),1981
3. Kahan F. M. H. Kropp J. G. Sundelof and J. Birnbaum. 1983. Thienamycin: development of imipenem-cilastatin. J. Antimicrob. Chemother. 12(Suppl. D):1-35.
4. Antibacterial activity of a new stabilized thienamycin, N-formimidoyl thienamycin, in comparison with other antibiotics;Kesado T.;Antimicrob. Agents Chemother.,1980
5. Kropp H. J. G. Sundelof J. S. Kahan J. Huber D. Bohn L. Gerckens F. M. Kahan and J. Birnbaum. 1983. Program Abstr. 23rd Intersci. Conf. Antimicrob. Agents Chemother. abstr. 331.
Cited by
41 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献