Fluoroquinolone resistance protein NorA of Staphylococcus aureus is a multidrug efflux transporter-Reference-Cited by-同舟云学术

Fluoroquinolone resistance protein NorA of Staphylococcus aureus is a multidrug efflux transporter

Published:1993-01 Issue:1 Volume:37 Page:128-129
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Neyfakh A A¹,Borsch C M¹,Kaatz G W¹

Affiliation:

1. Department of Medicinal Chemistry and Pharmacognosy (M/C 781), University of Illinois, Chicago 60680.

Abstract

The gene of the Staphylococcus aureus fluoroquinolone efflux transporter protein NorA confers resistance to a number of structurally dissimilar drugs, not just to fluoroquinolones, when it is expressed in Bacillus subtilis. NorA provides B. subtilis with resistance to the same drugs and to a similar extent as the B. subtilis multidrug transporter protein Bmr does. NorA and Bmr share 44% sequence similarity. Both the NorA- and Bmr-conferred resistances can be completely reversed by reserpine.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.37.1.128

Reference7 articles.

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4. Efflux mediated multidrug resistance in Bacillus subtilis: similarities and dissimilarities with the mammalian system;Neyfakh A. A.;Proc. Natl. Acad. Sci. USA,1991

5. A point mutation in the norA gene is responsible for quinolone resistance in Staphylococcus aureus;Oshita Y.;Biochem. Biophys. Res. Commun.,1990

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