Endocannabinoids Inhibit the Growth of Free-Living Amoebae-Reference-Cited by-同舟云学术

Endocannabinoids Inhibit the Growth of Free-Living Amoebae

Published:2010-07 Issue:7 Volume:54 Page:3065-3067
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Dey Rafik¹,Pernin Pierre¹,Bodennec Jacques¹

Affiliation:

1. Université de Lyon, Lyon, F-69003, France, and Université Lyon 1, CNRS, UMR 5123, Laboratoire de Physiologie Intégrative Cellulaire et Moléculaire, Villeurbanne, F-69622, France

Abstract

ABSTRACT The cannabinoid Δ 9 -tetrahydrocannabinol inhibits the growth of some pathogenic amoebae in vitro and exacerbates amoebic encephalitis in animal models. However, the effects of endogenous cannabinoids on amoebae remain unknown. Therefore, we tested several endocannabinoids ( N -acyl ethanolamines and 2- O -acyl glycerol) on different genera of amoebae. The results showed that all of the endocannabinoids tested inhibit amoebic growth at subpharmacological doses, with 50% inhibitory concentrations ranging from 15 to 20 μM. A nonhydrolyzable endocannabinoid had similar effects, showing that the inhibition seen results from endocannabinoids per se rather than from a catabolic product.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01825-09

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