Efficacy of a Cap-Dependent Endonuclease Inhibitor and Neuraminidase Inhibitors against H7N9 Highly Pathogenic Avian Influenza Virus Causing Severe Viral Pneumonia in Cynomolgus Macaques-Reference-Cited by-同舟云学术

Efficacy of a Cap-Dependent Endonuclease Inhibitor and Neuraminidase Inhibitors against H7N9 Highly Pathogenic Avian Influenza Virus Causing Severe Viral Pneumonia in Cynomolgus Macaques

Published:2021-02-17 Issue:3 Volume:65 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Suzuki Saori¹^ORCID,Nguyen Cong Thanh¹^ORCID,Ogata-Nakahara Ayako¹,Shibata Akihiro²,Osaka Hiroyuki²,Ishigaki Hirohito¹,Okamatsu Masatoshi³,Sakoda Yoshihiro³⁴,Kida Hiroshi⁴⁵⁶,Ogasawara Kazumasa¹,Itoh Yasushi¹^ORCID

Affiliation:

1. Division of Pathogenesis and Disease Regulation, Department of Pathology, Shiga University of Medical Science, Otsu, Shiga, Japan

2. Exotic Disease Inspection Division, Laboratory Department, Animal Quarantine Service, Ministry of Agriculture, Forestry and Fisheries, Tokoname, Aichi, Japan

3. Laboratory of Microbiology, Department of Disease Control, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Hokkaido, Japan

4. Global Institution for Collaborative Research and Education, Hokkaido University, Sapporo, Hokkaido, Japan

5. National Research Center for the Control and Prevention of Infectious Diseases, Nagasaki University, Nagasaki, Japan

6. Research Center for Zoonosis Control, Hokkaido University, Sapporo, Hokkaido, Japan

Abstract

H7N9 highly pathogenic avian influenza virus (HPAIV) infection in a human was first reported in 2017. A/duck/Japan/AQ-HE29-22/2017 (H7N9) (Dk/HE29-22), found in imported duck meat at an airport in Japan, possesses a hemagglutinin with a multibasic cleavage site, indicating high pathogenicity in chickens, as in the case of other H7 HPAIVs.

Funder

Japan Agency for Medical Research and Development

Ministry of Education, Culture, Sports, Science and Technology

MEXT | Japan Society for the Promotion of Science

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01825-20

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5. Epidemiology, Evolution, and Pathogenesis of H7N9 Influenza Viruses in Five Epidemic Waves since 2013 in China

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