Affiliation:
1. Department of Rheumatology and Clinical Bacteriology, University of Göteborg, Sweden.
Abstract
Staphylococcus aureus arthritis is usually caused by bacteremia and is highly destructive. Controlled studies on septic arthritis in humans are difficult to perform, because the time of onset of the infection is unknown. Animal models of bacterial arthritis make it possible to control important variables in experimental studies. We present a mouse model of S. aureus arthritis in which the intravenous administration of 10(7) cells of S. aureus LS-1 induced arthritis or osteitis or both within 3 weeks in 80 to 90% of the mice. Signs of arthritis emerged within the first few days after the injection. An interesting finding was that the S. aureus strain used in this study binds bone sialoprotein, a glycoprotein known to be specifically localized to bone tissue. This new model of S. aureus arthritis enables the study of the kinetics of joint destruction and the host-bacterium relationship as well as therapeutical approaches to septic arthritis and osteomyelitis.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Immunology,Microbiology,Parasitology
Reference29 articles.
1. Outbreak of spontaneous staphylococcal arthritis and osteitis in mice;Bremell T.;Arthritis Rheum.,1990
2. Isolation and characterization of two sialoproteins present in bone calcified matrix;Franzen A.;Biochem. J.,1985
3. Infectious arthritis complicating rheumatoid arthritis and other chronic rheumatic disorders;Goldenberg D. L.;Arthritis Rheum.,1989
4. Goldenberg D. L. 1989. Bacterial arthritis p. 1567-1585. In W. 0. Kelly E. D. Harris S. Ruddy and C. B. Sledge (ed.) Textbook of Rheumatology 3rd ed. W. B. Saunders Co. Philadelphia.
5. Experimental models of bacterial arthritis;Goldenberg D. L.;J. Rheumatol.,1983
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