A Glu-Glu-Tyr Sequence in the Cytoplasmic Tail of the M2 Protein Renders Influenza A Virus Susceptible to Restriction of the Hemagglutinin-M2 Association in Primary Human Macrophages

Author:

Bedi Sukhmani1,Mudgal Rajat1,Haag Amanda1,Ono Akira1ORCID

Affiliation:

1. Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan, USA

Abstract

Human MDMs represent a cell type that is nonpermissive to particle formation of influenza A virus (IAV). We previously showed that close proximity association between viral HA and M2 proteins is blocked in MDMs.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

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