Cell Wall Chitosan Is Necessary for Virulence in the Opportunistic Pathogen Cryptococcus neoformans-Reference-Cited by-同舟云学术

Cell Wall Chitosan Is Necessary for Virulence in the Opportunistic Pathogen Cryptococcus neoformans

Published:2011-09 Issue:9 Volume:10 Page:1264-1268
ISSN:1535-9778
Container-title:Eukaryotic Cell
language:en
Short-container-title:Eukaryot Cell

Author:

Baker Lorina G.¹,Specht Charles A.²,Lodge Jennifer K.¹

Affiliation:

1. Department of Molecular Microbiology, Washington University School of Medicine, 660 S. Euclid Avenue, St. Louis, Missouri 63110

2. Department of Medicine, University of Massachusetts, 364 Plantation Street, Worcester, Massachusetts 01605

Abstract

ABSTRACT Cryptococcus neoformans is an opportunistic fungal pathogen that causes meningoencephalitis. Its cell wall is composed of glucans, proteins, chitin, and chitosan. Multiple genetic approaches have defined a chitosan-deficient syndrome that includes slow growth and decreased cell integrity. Here we demonstrate chitosan is necessary for virulence and persistence in the mammalian host.

Publisher

American Society for Microbiology

Subject

Molecular Biology,General Medicine,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/EC.05138-11

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