Effect of Calcium Carbonate on Bioavailability of Orally Administered Gemifloxacin

Abstract

ABSTRACT We investigated the effect of calcium carbonate on the oral bioavailability of gemifloxacin. Gemifloxacin was administered alone, 2 h before, simultaneously, or 2 h after calcium carbonate in 16 volunteers. Data for 320 mg of gemifloxacin alone were as follows: maximum concentration of drug in serum ( C max ),13 μg/ml; half-life, 7.33 h; and area under the concentration-time curve from 0 h to infinity (AUC ∞ ), 6.79 μg · h/ml. Only simultaneous coadministration of calcium carbonate reduced C max (−17%) and AUC ∞ (−21%) significantly.