Effect of Calcium Carbonate on Bioavailability of Orally Administered Gemifloxacin-Reference-Cited by-同舟云学术

Effect of Calcium Carbonate on Bioavailability of Orally Administered Gemifloxacin

Published:2003-07 Issue:7 Volume:47 Page:2158-2160
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Pletz M. W.¹,Petzold P.¹,Allen A.²,Burkhardt O.¹,Lode H.¹

Affiliation:

1. Department of Chest and Infectious Diseases, City Hospital E. v. Behring, Free University of Berlin, Germany

2. Clinical Pharmacokinetics Department, GlaxoSmithKline Laboratories, Greenford, Middlesex, United Kingdom

Abstract

ABSTRACT We investigated the effect of calcium carbonate on the oral bioavailability of gemifloxacin. Gemifloxacin was administered alone, 2 h before, simultaneously, or 2 h after calcium carbonate in 16 volunteers. Data for 320 mg of gemifloxacin alone were as follows: maximum concentration of drug in serum ( C max ),13 μg/ml; half-life, 7.33 h; and area under the concentration-time curve from 0 h to infinity (AUC ∞ ), 6.79 μg · h/ml. Only simultaneous coadministration of calcium carbonate reduced C max (−17%) and AUC ∞ (−21%) significantly.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.47.7.2158-2160.2003

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