Antimicrobial activities of beta-lactam antibiotics and gentamicin against penicillin-susceptible and penicillin-resistant pneumococci

Author:

Gross M E1,Giron K P1,Septimus J D1,Mason E O1,Musher D M1

Affiliation:

1. Medical Service, Veterans Affairs Medical Center, Houston, TX 77030, USA.

Abstract

The MICs of penicillin and cefotaxime for a range of penicillin-susceptible and penicillin-resistant isolates of Streptococcus pneumoniae were unchanged by the addition of gentamicin. In time-kill studies the rate of killing was greater for 18 of 20 isolates in the presence of gentamicin. However, mean differences in killing after 6 h of incubation were modest, not exceeding 1 log10 unit.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Reference10 articles.

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2. In vivo antibiotic synergism: contribution of animal models;Fantin B.;Antimicrob. Agents Chemother.,1992

3. Dilemma in diagnosis and management of cephalosporin-resistant Streptococcus pneumoniae meningitis;Friedland I. R.;Pediatr. Infect. Dis. J.,1993

4. Interaction between betalactam antibiotics and gentamicin against Streptococcus pneumoniae in vitro and in vivo. Acta;Frimodt-Moller N.;Pathol. Microbiol. Immunol. Scand. Sect. B,1987

5. The in-vitro activity of combinations of penicillin and gentamicin against penicillin-resistant and penicillin-sensitive Streptococcus pneumoniae;Haynes J.;J. Antimicrob. Chemother.,1986

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